Effects of trypan blue and Niagara blue 2B on the in vitro absorption of ions by the rat visceral yolk sac.
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چکیده
منابع مشابه
Accumulation of DNA, RNA, and protein by cultured rat embryos following maternal administration of a teratogenic dose of trypan blue.
The effect of trypan blue on the rates of DNA, RNA, and protein accumulation in rat embryos was investigated using a system of whole embryo culture. Embryos were isolated on the 10th gestational day (sperm day = Day 0) either 4 or 24 hr after maternal injection. The cultivation period was for 24 or 42 hr. The rate of DNA and RNA accumulation in the embryo following either a 4- or 24-hr previous...
متن کاملThe effect of trypan blue on the growth of the rat embryo in vivo.
In a previous paper (Berry, 1968) it has been demonstrated, by comparison of in vivo and in vitro growth of the rat foetus, that it is possible to dissociate growth and differentiation in the rat. In a series now exceeding 1000 embryos it is evident that for a given somite number the protein content of an animal developing in vitro might be less than half that of the normal control, suggesting ...
متن کاملThe relationship of chemical structure to teratogenic activity among bisazo dyes: a re-evaluation.
Although the potency of trypan blue as a teratogenic agent in rodents has been known for almost twenty years the mechanism of its action remains obscure. The dye produces a variety of biological effects (see review by Beck & Lloyd, 1966) and most of these have at some time been suggested as possibly relevant to its teratogenicity. The investigation of such correlations would clearly be assisted...
متن کاملTrypan blue induced teratogenesis of rat embryos cultivated in vitro.
Trypan blue is known to produce embryonic abnormalities in a wide variety of animals, including rats (Gillman, Gilbert, Gillman & Spence, 1948), mice (Waddington & Carter, 1953; Hamburgh, 1954), amphibians (Waddington & Perry, 1956), chickens (Beaudoin & Wilson, 1958;Stephan & Sutter, 1961), rabbits (Ferm, 1956), and hamsters (Ferm, 1958). Studies on the teratogenic action of this dye have also...
متن کاملPergamon Press Ltd . Printed in Great Britain . SERUM PROTEINS AND TERATOGENESISI
Observations have been reported which suggest that altered electrophoretic patterns of the serum proteins may accompany pregnancies that terminate in the birth of abnormal offspring . The teratogenic disazo dye, trypan blue, has been shown to cause alterations in the proteins of the maternal serum of pregnant rabbits and in the protein composition of the 9-day rabbit embryo yolk sac fluid (1,2,...
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عنوان ژورنال:
- Journal of embryology and experimental morphology
دوره 22 1 شماره
صفحات -
تاریخ انتشار 1969